Antiadhesion and antibiofilm potential of Fagonia indica from Cholistan desert against clinical multidrug resistant bacteria

Abstract High resistance to antimicrobials is associated with biofilm formation responsible for infectious microbes withstand severe conditions. Therefore, new alternatives are necessary as inhibitors control infections. In this study, the antimicrobial and antibiofilm activities of Fagonia indica extracts were evaluated against MDR clinical isolates. The extract exhibited its effect by altering adherence disintegration bacterial cell wall. has antibacterial minimum inhibitory concentration (MIC) values ranging from 125 500 µg mL-1 bactericidal (MBC) value was 500-3000 multidrug resistant (MDR) had maximum effects chloroform on observed Staphylococcus aureus (71.84%) followed Klebsiella pneumoniae (70.83%) after 48 hrs showing that inhibition also time dependent. Our results about protein leakage indicated isolates treated showed K. (59.14 mL-1) S. (56.7 mL-1). Cell attachment assays resulted in a 43.5-53.5% polystyrene surface. revealed significantly inhibited among isolates, therefore, could be applied agents cost effective inhibitor these